P314 Cystic fibrosis related to bone disease in children: can it be predicted?

Cystic fibrosis (CF) -related bone disease (CFBD) is an important complication of CF, and low BMD in childhood a precursor CFBD. Here, we aimed to investigate turnover biomarkers, including osteocalcin (OC), receptor activator nuclear factor kappa B ligand (RANKL) osteoprotegerin (OPG) relation children with CF (cwCF). We also evaluated factors which could affect particular emphasis on free fat mass (FFM), forced expiratory volume 1 s (FEV1), hand grip strength (HGS), functional capacity physical activity. Sixteen cwCFaged 8–18 years (case group) 64 cwCF without (control were enrolled. Serum RANKL, OC, OPG determined by immunoenzymatic assays. Multiple parameters pancreatic status, lung functions, body index (BMI), FFM measured bioelectric impedance analysis (BIA), 6-minute walk test, vitamin D, nutritional intake, HGS, activity, serum urine biomarkers compared between the two groups. found similar levels RANKL (p = 0.501), OC 0.445), 0.380), RANKL/OPG ratio 0.449) comparison BMD. BMI z-score < 0.001), FFMI FEV1 0.007), right-HGS (%pred) 0.009) significantly differed Multivariate linear regression revealed that only predicted HGS %pred. OPG, did not predict cwCF. %pred non-invasive practical methods best predictors